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Moreover, the GLORYx study included the public release of compiled data including a large reference set and smaller test set of molecules and associated reactions to expand on freely available training and testing resources

14 While genetic and pharmacological inhibition of GSH synthesis has provided insight into the consequences of GSH depletion, it has been very difficult to restore GSH abundance in disease models

doi: 10.3390/antiox5040037 431 LamenzaFFUpadhayaPRothPShresthaSJagadeeshaSHornNet al

In addition, administration of the drug in a thrombotic mouse model revealed a significant decrease in the area of cerebral edema, the area of cerebral infarction, and the expression of pro-inflammatory factors in mice (Keuters et al., 2021)

Podmore ID, Griffiths HR, Herbert KE, Mistry N, Mistry P, Lunec J

Induced pluripotent stem cells with mtDNA mutations retain high levels of ROS (63), although this phenotype can be rescued via treatment with antioxidants such as n-acetyl-l-cysteine (NAC)