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Thus non-optimal temperature is not the official cause of death in the vast majority of these cases but rather a contributing factor that can be ascertained only by investigating statistical relationships between daily temperature and death rates

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It should be noted that the effect of B12 was pleiotropic, that is, it regulates several metabolic or intracellular signaling pathways maladjusted by COVID-19 despite the glucocorticoid treatment that patients received during hospitalization

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These aren't incremental improvements on the same mechanism