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This can manifest as irregular menstrual cycles, anovulation, difficulty getting pregnant, or miscarrying

Multifunctional strands in tight junctions

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Wang X, Li J, Dong K, Lin F, Long M, Ouyang Y, Wei J, Chen X, Weng Y, He T, Zhang H

In addition, most tumour cell types possess IGF1 receptors and conditions in the tumour microenvironment, such as hypoxia, can lead to enhanced responsiveness to IGF1