foxo4-dri senolytic 2023 2024 induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation CHK2-USP37 axis stabilizes FOXO4 to
CHK2 USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis PNAS The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications Senolytic Peptide FOXO4 DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes PMC Senolytic therapeutics: An emerging treatment modality for osteoarthritis ScienceDirect foxo4 dri peptide senolytic 2023 2024 study FOXO4 DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53 serine 15 phosphorylation Full article: Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics
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