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HepAD38 cells, which had integrated HBV DNA composed of a 1.1-fold excess of the HBV genome, were kindly provided by Professor Ning-Shao Xia (Xiamen University, China) and maintained in DMEM (D6429, SigmaAldrich, Germany) containing 10% FBS, 1% PS and 400 g/mL G418 (Merck)

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This work was funded by the U.S

As a result, Nrf2 migrates to the nucleus where it promotes the expression of genes involved in antioxidant defense (208) ( Figure 2B )

Management of NASH should focus on the restitution of metabolic derangements and halting inflammatory, fibrogenic, and carcinogenic pathways