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Dark spots or hyperpigmentation, including those left behind after acne heals (called post-inflammatory hyperpigmentation), are caused by excess melanin

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TrxR transfers electrons from NADPH to reduce oxidized thioredoxin (Trx-S 2 ) to Trx-(SH) 2 , which provides reducing equivalents in the enzymatic removal of H 2 O 2 and other organic hydroperoxides by Prx [33]