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Rather than relying on assumptions or genetic results alone, a more evidence-based approach is to assess functional biomarkers such as homocysteine and interpret these alongside the wider clinical picture

3.5.2 GPX4-regulated neutrophil ferroptosis triggers autoimmunity Neutrophilscentral effectors of innate immunityare now implicated in the pathogenesis of SLE not only through classical functions (e.g., autoantibody formation and TNF- release) but also via dysregulated iron metabolism and ferroptosis

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Even in such cases, it is often mild and self-resolving with supportive care

We hypothesized that old C57BL/6J mice would have the following: (a) naturally-occurring ACD