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Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition

1 Alcohol use may be light and intermittent, involve binge drinking, or be heavy and/or chronic

Molecular docking The protein structures of p53 (PDB ID: 8E7A) and HDAC7 (PDB ID: 3C0Y) were obtained from the Protein Data Bank ( Ligands and receptor proteins were preprocessed using AutoDock Tools 1.5.6, and molecular docking was performed using AutoDock Vina

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Collectively, through the series of in vivo and in vitro studies outlined above, the findings of the present study suggest that DAPA could delay DN progression by inhibiting ferroptosis through activation of the Nrf2/HO-1 signaling pathway (Fig

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