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This causes increased neuroinflammation in human brain vascular pericytes (Table 1), which further leads to neurovascular unit disruption and immune cell transmigration across the BBB ( TABLE 1 Summary of cocaine- and methamphetamine-induced neurotoxicity based on their effect on the structural integrity of the blood brain barrier and their respective molecular pathways

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Notably, research exploring combinations of GHRH analogs and GHRP-2 observed more pronounced increases in pulsatile GH secretion than with either peptide alone, suggesting potential synergistic interactions

BMJ 348 , g2547 (2014)

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Thus, dietary substitutions of unsaturated fat for saturated fat, as well as a reduction in consumption of trans fatty acids, is recommended to help lower serum cholesterol and the risk of heart disease