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For the conjugation of Mn/TI@mHSA to cPLT, Mn/TI@mHSA NPs in PBS were first activated with sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, then concentrated using Amicon ultra-centrifugal filters (molecular weight cut-off 50 kDa) with 3000 g for 10 min and washed with PBS to remove unreacted linker

This is usually a gradual, subtle shift rather than a dramatic change

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Curcumin has low oral bioavailability in humans and it may undergo intestinal metabolism (Sharma et al., 2001)

PROVEAN yielded very poor correlations of = 0.44 ( p = 0.27), 0.59 ( p = 0.09), and 0.64 ( p = 0.05) for age of onset, disease severity, and clinical vitamin B 6 response, respectively

IGF-I is a polypeptide that belongs to the family of insulin-like growth factors similar in molecular structure to proinsulin and is a synthetic analog of insulin-like growth factor 1 (IGF-I