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The 2023 GRAS designation permits marketing as a dietary supplement ingredient but NOT as a therapeutic agent

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However, certain molecules, such as erastin and sulfasalazine can inhibit system XC and cause the depletion of cellular cysteine, leading to the impairment of the intracellular GSH homeostasis and ultimately, intracellular GSH deficiency and ferroptosis (44,45)

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doi: 10.1371/journal.pbio.2006203 53 ShuiSZhaoZWangHConradMLiuG

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