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To create molecularly focused therapies that can change the course of the illness rather than merely manage its symptoms, it is necessary to map the sequential path from airway to damage to systemic and neurological harm [107, 108]

TAMs, through their remarkable metabolic plasticity, modulate iron flux, redox balance, polyunsaturated fatty-acid (PUFA) availability, and glutathione-dependent antioxidant pathways, each of which directly influences ferroptotic vulnerability in neighboring tumor cells

Daily rest-activity patterns in the bipolar phenotype: a controlled actigraphy study

Mitochondria (Organelle Source of ROS) The mitochondria are the primary intracellular generator of ROS

Vitamin B3 (Niacin) : Important for DNA repair, cell signalling, and energy metabolism

These interventions could be alterations in lifestyle [105], modulating SASP, probiotics, antioxidants, inhibitors of NF-B and mTOR, and activators of Nrf2, sirtuins, and AMPK, as well as senolytic drugs