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population is a valuable tool for researchers and policy makers

Mol Cell 51:6879

GPX synthesis utilizes selenium via selenocysteine and homocysteine is derived from adenosylhomocysteine, and the latter was formed as a result of methylation reactions including methylation of selenium [44]

These mechanisms avoid the accumulation of damaged/dysfunctional proteins and of protein aggregates, which can reach a toxicity threshold when proteostasis is impaired [34, 35]