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Absorption: The oral absorption of vitamin B12 occurs exclusively in the terminal ileum of the small intestine

Additionally, Leptin, a hormone produced by adipose [fat] cells, may also contribute to a reduction in feed intake by decreasing the obese animals appetite (Smith and Sherman 759)

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The impact of B12 and Folate depletion extends deeply into the central nervous system, driving the cognitive impairment commonly referred to as brain fog