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IRE1/XBP1 signaling in tumor growth, angiogenesis, and chemoresistance In parallel to PERK, the IRE1/XBP1 branch of the UPR plays a critical role in sustaining tumor growth and mediating resistance to therapy

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This allowed us to define a compendium of proteins mediating mitochondrial translation as a mechanism to resolve mistranslation stress and hence genes involved in mitochondrial quality control (Fig