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Additionally, riboflavin must be transported within cells and into the mitochondria

agents are useful in methods of the present invention

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Together, these effects lead to the immunogenic cell death of tumor cells and alleviate PD-L1-mediated immune evasion, which further remodels the immunosuppressive TME and triggers a robust immune response, effectively inhibiting bilateral tumor progression and metastasis [76]

If the insert is intended for insertion into the vagina, it is called a vaginal insert, vaginal suppository, or pessary (2)