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During this critical period of vulnerability, neonate defences rely on breast milk protective factors, and the development of their own immune system increased by the breast milk, as well (67)

Cereblon-based PROTACs in clinical trials According to clinicaltrials.gov database, of the approximately 25 PROTACs currently in clinical trials, nineteen recruit the cereblon E3 ligase, the vast majority of which are intended for the treatment of cancer (Table 13)

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42 (6), e168e185 (2022)

Chiticaru et al

Trimethylamine N-oxide (TMAO), diet and cardiovascular disease