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Steroid-sparing treatments, including immunosuppressive agents and biologics such as hydroxychloroquine, can reduce dependence on corticosteroids and limit their associated damage (109)

The effects of diet, genetics and chemicals on toxicity and aberrant DNA methylation: an introduction

Int J Biochem Cell Biol 88:133144

The cerebrovascular adaptations to RT are supported by work from Thomas et al, who conducted 12 weeks of progressive RT (progression from 60%90% 1RM with repetitions lowering as intensity increases, 3 times per week) in healthy young adults and similarly observed increased cerebrovascular resistance and decreased pulsatility at rest

In vivo studies may be constrained by variations in genetic origins, environmental circumstances, and disease progression in animal models and humans

We thoroughly discussed the bidirectional role of ferroptosis in radiotherapy, providing new strategies and insights for improving tumor radiotherapy sensitivity and reducing radiation-induced injury in clinical practice