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Suresh Kumar et al

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An increase in the number of available structures of enzymes in protein structure databases solved by X-ray crystallography (particularly enzymes from pathogenic microbes), combined with recent improvements in computational methods applied to elucidate and understand enzyme function as well as the increasing pace of genome sequencing and annotation of microbes in the last decade, have opened up enormous opportunities to develop new antimicrobial targets as well as to discover new antimicrobial molecules

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