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Pain is present in the preclinical and initial stages of the disease and it is a cause of suffering and disability in patients with PD, causing a great impact on the quality of life and unfortunately, very often, pain goes unnoticed in clinical practice because usually the greatest attention is given to motor alterations

To avoid this, start with a lower amount and gradually increase as needed

Chen X, Zhao B, Qu Y, Chen Y, Xiong J et al

The second mechanism of action occurs downstream, in the liver

Trop Gastroenterol 32:167174 Lei S, Gu R, Ma X (2021) Clinical perspectives of isoniazid-induced liver injury

Notably, the diffusion of FITC-dextran was not observed, confirming that the excreted glucose was not the result of diffusion, but occurred via the glucose transporter (Supplementary Fig