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Options include: Topical azole antifungals : Clotrimazole, miconazole, or tioconazole creams or suppositories used for 1-7 days depending on formulation strength Oral fluconazole : A single 150 mg dose for uncomplicated infections, available by prescription Combination therapy : Topical treatments for external symptoms plus oral medication for internal infection Pregnant patients should use topical azole therapy for 7 days and avoid oral fluconazole

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In summary, mutations in DNMT3b, ZBTB24, CDCA7, and HELLS disturb the normal process of DNA methylation, which is critical to the pathogenesis of ICF syndrome (90)