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Although immune potentiators show promise, particularly in tumor immunotherapy, they are often associated with toxicity and systemic side effects due to rapid diffusion into circulation (Abhyankar et al

3 d, 48 h: Ctrl, n = 6 mice

doi: 10.1101/cshperspect.a020412 311 WatkinsSRobelSKimbroughIFRobertSMEllis-DaviesGSontheimerH

Can J Physiol Pharmacol 61:14411461 Metges CC, Yu Y-M, Cai W, Lu X-M, Wong S, Ajami A, Young VR (1999) Plasma L-5-oxoproline carbon and nitrogen kinetics in healthy young adults

The immunomodulatory effects of macrolide antibiotics in respiratory disease

(2020) showed that loss of SQOR in a mouse model of ulcerative colitis (UC) disrupts the intestinal epithelial barrier integrity and causes severe mitochondrial dysfunction