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Erastin induces cell death in two ways

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In STZ-induced DN mouse kidney sections, the outer mitochondrial membrane ruptured, mitochondrial crista disappeared, ACSL4 expression was significantly increased, the levels of oxidative products were elevated, and the level of GPX4 was decreased, indicating that ferroptosis was involved in STZ-induced DN [225]

Galloway, D.C., Blacke, D.G., Shepherd, A.G