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In plants, ROS are continuously produced under normal physiological conditions within membrane-bound organelles such as mitochondria, chloroplasts, and peroxisomes, as well as in other cellular compartments

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10.1007/s12035-023-03379-8 32 ChenY.GuoX.ZengY.MoX.HongS.HeH.et al (2023b)

Overexpression of COX2 is reported in many types of cancer, including cutaneous melanoma, which contributes to tumor progression and angiogenesis (225)

Viscosupplementation was first used in Europe and Asia, and was approved by the U.S Food and Drug Administration in 1997