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Targeted therapy and ototoxicity Newer therapies aimed at specific cancer types, such as tyrosine kinase inhibitors (TKIs), have been associated with vestibular dysfunction, though their precise ototoxic mechanisms remain under investigation

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Mechanism of action Calcium antagonists inhibit the influx of calcium ions through slow channels in vascular smooth muscle and cause relaxation of both coronary and peripheral arteries

It was also clear that expression of the immune-related genes pirk and PGRP-LB were decreased by MetR, suggesting attenuation of the inflammatory state in the aged gut (Fig

This is a scenario which overstresses the remaining beta cells, which are still capable of providing insulin in the diabetic metabolic state and thus gives rise also to more misfolded proinsulin (Lenzen 2017)

S5, S6A, S6B)