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RNAi-mediated inhibition of glutathione synthesis impaired survival of multiple colon cancer cell lines, and pharmacological targeting of this metabolic pathway reduced colonization in a primary patient-derived xenograft model

[Low et al 2007 1] [18] Function [edit] The activity of GSTs is dependent upon a steady supply of GSH from the synthetic enzymes gamma-glutamylcysteine synthetase and glutathione synthetase, as well as the action of specific transporters to remove conjugates of GSH from the cell

Kim SH, Zhong X, Kim W, Kim K, Suh YG, Kim C, Joe Y, Chung HT, Cha YN, Surh YJ (2018) Taurine chloramine potentiates phagocytic activity of peritoneal macrophages through up-regulation of dectin-1 mediated by heme oxygenase-1-derived carbon monoxide

MK-4 is the only menaquinone that is not produced by bacteria