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354,355 It has been postulated that inhibitors conforming to the substrate envelope exhibit a superior resistance profile by safeguarding against binding site mutations, which would otherwise impede access to the substrate envelope and significantly compromise natural substrate binding

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10.1016/j.biochi.2017.10.002 194 ZhangS.ZhongR.TangS.ChenL.ZhangH

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Rightmost panel: Influence of CSE overexpression (OE) on the viability of U2OS cells treated for 24 h with either RSL3 (5 M) or CHP (40 M), as measured with an ATP assay

JC-1 assay DCs were treated with GDEs (160 g/mL) for 24 h