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TRPV1 Channel Inhibition: Research published in Molecular Immunology (2023) identified a second direct analgesic mechanism ARA-290 specifically inhibits TRPV1 (Transient Receptor Potential Vanilloid 1) channel activity in peripheral nociceptors, increasing the pain threshold and relieving mechanical hypersensitivity independent of its anti-inflammatory IRR actions

Expert Opin Ther Targets 25(3):163166 Acknowledgements I would like to extend my sincere gratitude to CNDR, MIET for the excellent facilities throughout the production of this essay

doi: 10.3390/molecules23010238

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doi: 10.1016/j.cmet.2023.03.019 52 MiyaoMHirotsuATatsumiKTanakaT