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Conversely, genotoxic carcinogens such as arsenic, benzene, and ionizing radiation are generally described as non-threshold agents, meaning that even minimal doses may initiate cumulative molecular damage through DNA adduct formation, oxidative stress, or chromosomal instability [237,238]

Following liver resection, elevated bile salts activate FXR and upregulate IL-6/STAT3/c-JUN signaling to promote regeneration

Acetaldehyde, a carcinogenic byproduct of alcohol metabolism, can damage DNA and may exacerbate the carcinogenic effects of tobacco, thereby contributing to the development of lung cancer [134]

The commenter stated that lack of consistent WAC supply pricing updates has contributed to payment instability for these services and puts beneficiary access at risk

(2014) 127(Pt 12):26216