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"National Weather Service Staff Looks Back on the Tenth Anniversary of March 2nd 2012"

6) Various known anti-cancer drugs in the market are mostly used against various malignancies with the positive outcome however some of the cancer cells alter their protein expression or morphology to become irresponsive and achieve resistance

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doi: 10.2147/IDR.S129055 19 CastroC.CorrazeG.BastoA.LarroquetL.PanseratS.Oliva-TelesA

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Many epigenetic regulators are overexpressed in tumors and contribute to drug resistance mainly by inhibiting apoptosis, inducing autophagy and EMT, enhancing stemness, and activating multiple signaling pathways including the PI3K/Akt, Notchand NF-B pathways, etc