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doi: 10.1016/j.xinn.2023.100503 220 Martnez-SolanoLMaciaMDFajardoAOliverAMartinezJL

The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture)

26,68,69 At least two mechanisms have been proposed to explain the deficient IFN-I response: (1) previous studies have suggested that SARS-CoV employs various mechanisms to inhibit IFN response, especially through the components of its structural proteins such as M protein, 70 N protein, 71 open-reading frame 3a (ORF3a) protein, 72 and ORF6 protein

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Mice under caloric restriction self-impose a temporal restriction of food intake as revealed by an automated feeder system

Autophagy 12, 2069 (2016), Reactant(s): Mouse, Abstract Mild mitochondrial metabolic deficits by -ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimers disease: Banerjee, K., Munshi, S., et al