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Glutathione does not alter tirzepatide's half-life (approximately five days), absorption rate, or receptor binding affinity

95% CI, 0.614 to 0.325), consistent with the findings from the period effect analysis (Figures 7A,B)

UC will also aggravate the imbalance of gut microbiota

Through experimental methods such as molecular docking, CESTA, and non-targeted metabolomics, we found that SAC can act on the Keap1/Nrf2/GPX4 signaling axis and regulate glutathione metabolism, effectively inhibiting ferroptosis and oxidative damage in colonic epithelial cells, thereby alleviating UC