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The difficulties in the identification of the correct BGC could be because the biosynthetic pathway does not involve NRPSs for the amide-forming steps

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Furthermore, the covariates used to calculate the propensity score included body mass index, birth plurality, history of ICP, assisted reproductive technology, the severity of ICP, and skin itch

Emerging clinical strategies target ferroptosis and cuproptosis The clinical translation of therapies targeting ferroptosis and cuproptosis in gastrointestinal (GI) malignancies is in early stages, despite extensive preclinical evidence

However, the global shortage of liver donors and the high cost of transplantation mean that many patients either cannot access a liver transplant or cannot afford the procedure, often resulting in death (155)

down-regulation of monoamine function, brain inflammation, oxidative stress, neurotoxicity and longer-term neuroplastic changes that mediate craving)