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Dimer dissociation can be simply defined as a dimer ( M 2 ) dissociating into monomers ( M ) with conservation of mass, meaning that a single dimer dissociates into two monomers: Despite MS not being quantitative, the detected intensity of each species comprising a complex in equilibrium is dependent upon their relative concentrations in solution

Acknowledgements We thank Elisabeth Rushing (Institute of Neuropathology, University Hospital Zurich) for support with the analysis of histological sections and Friedhelm Bladt and Frank Jhrling (Merck, Darmstadt, Germany) for providing EMD1214063 and for helpful discussions

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Studies have revealed that alterations in the enzymatic activity or expression levels of CYP3A4 are key determinants of drug efficacy and toxicity [48]

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BRAF V600E mutation is associated with mTOR signaling activation in glioneuronal tumors