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As cells further engage in recycling with reversed GPI, more labelled carbon can be released as 13 CO 2 when glucose enters oxPPP for the second or third round, thus resulting in labelling enrichment in lower glycolysis 0.6, which corresponds to near full oxPPP but with no cycling, as expected (Fig

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Reactive oxygen species (ROS), produced via GSH-mediated pathways, can serve as danger-associated molecular patterns, stimulating dendritic cells and promoting T-cell expansion [82]

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