chac1 er stress glutathione degradation Long noncoding RNA GDIL acts as a scaffold for and XRN2 to promote platinum resistance of colorectal cancer through inhibition of The integrated stress response effector
The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2: Cell Reports GSH Related Enzymes GPx4, Chac1, and GSTs and Redox Regulation of Ferroptosis in Cancer Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect Frontiers The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications Frontiers CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine
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