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New York, NY: American Society for Microbiology Press

The discontinuation was driven by (Bergam, 2025) (Figure 2): the availability of newer, safer & more accurate alternative testing for MG including electrophysiological & antibody tests, as well as safety concerns (bradycardia & respiratory complications) limited diagnostic reliability (with both false-positive and false-negative results) The decision to remove edrophonium as an available (alternative) diagnostic test has been challenged (Keritam et al, 2026)

Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress

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While these findings highlight the potential of EMS as a complementary strategy, future research could explore its application in clinical populations with limited physical capacity, where traditional RT may be less feasible (Thapa et al., 2023)

Keeping in mind health-promoting properties of nutraceuticals along with their great therapeutic potential and safety profile, there is a permanently growing demand on the application of mitochondria-relevant nutraceuticals