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10.1039/D1FO01287H 17

MOTS-c acts on mitochondrial signaling through AMPK pathway activation

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While non-Hispanic White individuals have been reported to have a higher incidence of coronary artery disease than other racial groups, Black individuals have higher risks of fatal heart attack or stroke than White individuals

However, it shows little effect on glucose regulation in rodents and has been linked to rare hyperglycemia events in ALS patients (199, 201205), suggesting that, like hydralazine, it is not optimal for diabetes therapy