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Targeting the TGF pathway for cancer therapy

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It is plausible that anti-IL-17 biologic affect these processes, as it has been reported that IL-17A and IL-17E contribute to IPF, primary biliary cirrhosis, and salivary gland fibrosis through the activation of epithelial-mesenchymal transition (EMT), which leads to fibroblast proliferation and differentiation in myofibroblasts [238]

Then the formulation and production process were optimized

Resveratrol Attenuates High-Fat DietInduced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression