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Fournir la forme mthyle procure donc un coenzyme qui ne dpend pas des tapes de conversion requises par la cyanocobalamine, ce qui est la principale raison de son choix dans les contextes de recherche axs sur la mthylation et le mtabolisme un carbone

Recent studies in solid cancers have found that APR-246 can also induce p53-independent cell death

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10.14814/phy2.14453 Physiol Rep

The hallmarks of ferroptosis Ferroptosis is a cell death pathway that has been the focus of increasing investigation due to its theorized role in numerous human diseases

Therefore, we aimed to identify factors affecting PK variability of busulfan in pediatric allogeneic hematopoietic cell transplantation (HCT) recipients and investigate the effect of glutathione S-transferase (GST) activity on busulfan metabolism using a semi-mechanistic population PK model