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Similarly, ICV pretreatment or peripheral post-treatment with the DEETGE-Cal-Tat peptide was also able to decrease Keap1-Nrf2 interaction in the rat hippocampal CA1 region after global cerebral ischemia (GCI) and, as a consequence, to induce Nrf2 target genes and a powerful neuroprotection of hippocampal-dependent cognitive function after GCI [302]

[DOI] [PubMed] [Google Scholar] 166.Akkaya S., Ulusoy D.M

Sun sensitivity increases dramatically within 48-72 hours of starting treatment, making skin burn 10 times faster than normaleven brief outdoor exposure can cause severe sunburn

The etiology of HD is primarily attributed to the huntingtin protein (HTT) gene contains an abnormal number of CAG repeats, leading to the amplification of trinucleotide repeat sequences (TNR), specifically the CAG codon, resulting in the synthesis of an abnormal protein with an expanded polyglutamine (polyQ) tract (210, 211)

GHK-Cu upregulates the expression of superoxide dismutase (SOD) and other endogenous antioxidant enzymes, helping skin combat the free radical damage that accelerates aging

DISCLOSURES: The authors declare no conflicts of interest relevant to the content of this article