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Phase I uses cytochrome P450 enzymes to transform the toxins, and often what is produced here, called intermediates, are incredibly toxic to the body so an additional transformation is required

Or stand at the edge of a cold river and just wade right in and be able to resist that mammalian dive reflex, that [Greenfield mimics gasping] sharp intake of breath that you'd normally take in

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However, the mechanism of the progress is still unclear

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