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Brendler, T., & Williamson, E

(PubMed) Mills JL, Scott JM, Kirke PN, et al

These reactions are less common than mild local reactions but may require immediate medical attention

In March 2026, Roche reported that the Phase 2 ZUPREME-1 trial produced mean body-weight reductions of up to 10.7% at week 42 versus 1.7% with placebo under the reported analysis

Its still unclear which specific components of the NF-B signaling pathway are critical and how they might function during the differentiation of exhausted T cells