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Representative complexes are given in (Figure \(\sf{\PageIndex{17 \)

Beyond its cytoskeletal effects, TB-500 forms functional complexes with PINCH (particularly interesting new cysteine-histidine-rich protein) and integrin-linked kinase (ILK), activating the survival kinase Akt while inhibiting TNF--induced NF-B activation through blocking of RelA/p65 translocation

What makes ARA-290 different ARA-290 was engineered from the tissue-protective domain of erythropoietin (EPO)

antibodies that were elicited by infection with or vaccination against a closely related serotype, termed cross-reactive antibodies

Clinical Trial Findings Status: SS-31 (Elamipretide) is currently or has been in Phase 2 and Phase 3 clinical trials for several conditions, including Primary Mitochondrial Myopathy (PMM), Barth syndrome, and Heart Failure