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Increasing fatty acid and ketone metabolism after a ketogenic diet also attenuated reductions in ATP, NAD, mitochondrial fragmentation, and myelination in a murine diffuse axonal injury model, while treatment with ketone bodies reduced neuronal/myelin damage induced by glucose deprivation in vitro [96]

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2363-C REDUCTION OF TGF- AND IMPROVEMENT OF FIBROSIS AFTER OPTIMIZATION OF FECAL MICROBIOTA TRANSPLANT WITH AN ENDOSCOPIC-PLACEMENT HYDROGEL IN A MURINE MODEL OF STEATOHEPATITIS WITH FIBROSIS Ramon Bartoli Sole 1,2 , Ignacio Iborra 3 , Maria Torner Sim 3 , Alba Ardevol Ribalta 3 , Helena Masnou 2,3 and Rosa Maria Morillas 1,2,3 , (1)Ciberehd, (2)Germans Trias I Pujol Research Institute (IGTP), (3)Hospital Germans Trias I Pujol Background: Gut microbiota dysbiosis has become a key factor in the development and progression of non-alcoholic steatohepatitis (NASH) by influencing the immune and metabolic systems and increasing gut mucosa permeability to bacterial products, which in turns, activates the secretion of proinflammatory and profibrotic cytokines