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Additional information Edited by G Kroemer Rights and permissions About this article Cite this article Troyano, A., Sancho, P., Fernndez, C

The FDA-approved Mylotarg (gemtuzumab ozogamicin) utilizes an acid-sensitive hydrazone linker to efficiently release the DNA-damaging agent calicheamicin within lysosomes, achieving precise targeting of leukemia cells