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The effects of micro- and nanoplastics on the central nervous system: a new threat to humanity

Microbes 9, 2134

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Their results showed that reducing Rb protein expression using shRNA in the presence of sorafenib treatment increased the amount of ROS in the mitochondria of HCC cells to some extent, which increased the sensitivity of HCC cells to sorafenib-induced ferroptosis, probably because silencing Rb protein increased the expression of GPX4 mRNA in the cells, suggesting that Rb protein silencing resulted in HCC cellular susceptibility to sorafenib may be caused by an imbalance in cellular antioxidant capacity

10.1016/j.molcel.2019.02.019