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Salivary levels of valproic acid correlate poorly with serum levels, partly due to valproate's weak acid property (p K a of 4.9)

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These mutant AR proteins bind to other steroid hormones, such as estrogen, progesterone and glucocorticoids, which induce the activation of AR transcriptional activity resulting in prostate cancer growth 144

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Upon admission to the hospital he was in a deep coma and had generalized hypotonicity and no response to pain