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Proper storage ensures the vitamin maintains its effectiveness, reducing the risk of administering an ineffective dose

Proc Natl Acad Sci USA 114:31863191 Gonfloni S, Di Tella L, Caldarola S, Cannata SM, Klinger FG, Di Bartolomeo C, Mattei M, Candi E, De Felici M, Melino G et al (2009) Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death

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However, because this product provides doses far above the daily nutritional requirements (for instance 100 mg of B vs an RDA of ~1.4 mg), its use in pregnancy must be carefully considered

After structural refinement of the X-ray structure of TGR into the cryo-EM map obtained at 3.6 resolution (as estimated by the gold-standard Fourier shell correlation at 0.143 Supplementary Fig