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The rate-limiting enzyme in this pathway is Indoleamine 2,3-dioxygenase 1 (IDO-1), which is upregulated by pro-inflammatory agents such as interferon- (IFN-) and tumor necrosis factor-alpha (TNF-), interleukin-1 (IL-1), interleukin-12 (IL-12), all cytokines that are released during inflammatory responses (Yang et al., 2024)

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Consequently, they all complement ME-3s activities

10.1038/17135 Nature 190 SuyamaK.WatanabeM.SakabeK.OkadaY.MatsuyamaD.KuroiwaM.et al (2011)

The expected results were obtained, i.e., liver and kidney homogenates were generally shown to be associated with higher catalase activity than other tissues (Fig